Jump directly to the page contents

Infrafrontier the European infrastructure for phenotyping and archiving of model mammalian genomes

Activity Code: INFRA-2007-2.2-01
Coordinator: Prof. Martin Hrabé de Angelis, Helmholtz Zentrum München- German Research Center for Environmental Health


Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper characterization (Mouse Clinics), archiving and dissemination of mouse disease models to the research laboratories.

The current capacities, governance structures and funding strategies of existing infrastructures will not be able to serve the upcoming urgent needs. Thus it is imperative to organise and establish now an efficient distributed infrastructure for the phenotyping, archiving and dissemination of mouse models on a well concerted, large-scale and pan-European level. This will be a prerequisite for maintaining Europe s leading role in the functional annotation of the mouse genome. Infrafrontier will guarantee the accessibility of mouse models and will be essential to facilitate their exploitation. Infrafrontier integrates 15 European laboratories with exceptional track records to implement and run large-scale infrastructures.

Project Details:

Start Date: 01.03.2008
End Date: 28.02.2011
EU Contribution: 4.5 Mio. Euro
Total Costs: 5.73 Mio. Euro
Funding Scheme: Integrating activities / e-infrastructures / preparatory phase
Administrative Contact Person:
Dr Jürgen Ertel, ertel@helmholtz-muenchen.de
Scientific Coordinator: Prof. Martin Hrabé, hrabe@helmholtz-muenchen.de 
Project Website:http://www.infrafrontier.eu/


  • Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt, Germany
  • Ministero del Lavoro, della Salute e delle Politiche Sociali, Italy
  • Ministerstvo skolstvi Mladeze a Telovychovy, Czech Republic
  • Biocev Z.S.P.O., Czech Reublic
  • Toronto Centre for Phenogenomics INC., Canada
  • Genome Research Limited, United Kingdom
  • Fundacion para el Conocimiento Madrimasd, Spain
  • Ministerio de Salut - Generalitat de Catalunya, Spain
  • Kobenhavns Universitet, Denmark
  • Vetenskapsradet - Swedish Research Council, Sweden
  • Veterinärmedizinische Universität Wien, Austria
  • Centre European de Recherche en Biologie et Medecine, France
  • Helmholtz-Zentrum für Infektionsforschung GmbH, Germany
  • Agencia Estadal Consejo Superior de Investigaciones Cientificas, Spain
  • European Molecular Biology Laboratory, Germany
  • Universitat Autonoma de Barcelona, Spain
  • Biomedical Sciences Research Center Alexander Fleming, Greece
  • Oulun Yliopisto, Finland
  • Geniki Grammatia Erevnas Kai Technologias, Ypourgio Anaptixis, Greece
  • Bundesministerium für Bildung und Forschung, Germany
  • Medical Research Council, United Kingdom
  • Consiglio Nazionale delle Ricercie, Italy
  • Karolinska Institutet, Sweden
  • Centre National de la Recherche Scientifique, France
  • Fundacao Calouste Gulbenkian, Portugal
  • Fundacion Parque Cientifico de Madrid-FPCM, Spain
  • Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V., Germany
  • Institut National de la Santé et de la Recherche Medicale (INSERM), France