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Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

Project Reference: 312325
Activity Code: INFRA-2012-1.1.4.
Coordinator:Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt


The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:

  •  Develop a series of mutant alleles for every gene in the mouse genome;
  •  Determine the phenotypic consequences of each mutation;
  •  Identify mouse models for the complete disease spectrum in humans.

To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows:

  • Contribute to resource development by archiving of 1215 new mouse mutant lines;
  • Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities;
  • Offer a specialized axenic service to produce, maintain and to distribute germ-free mice;
  • Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database;
  • Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation;
  • Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop;
  • Offer state of the art cryopreservation and phenotyping training courses;
  • Benchmark Infrafrontier services with other major repositories.

The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy..

Project Details:

Start Date: 2013-01-01
End Date: 2016-12-31
EU Contribution: EUR 9 900 000
Total Costs: EUR 12 423 360 
Programme Acronym: FP7-Infrastructures
Subprogramme Area: INFRA-2012-1.1.4.
Administrative Contact Person: Florian BERBERICH (Dr)
Funding Scheme: Combination of CP and CSA


  • Agencia Estatal Consejo Superior De Investigaciones Cientificas, España
  • Consiglio Nazionale Delle Ricerche, Italia
  • Karolinska Institutet, Sverige
  • Oulun Yliopisto, Finland
  • Katholieke Universiteit Leuven, Belgique
  • Tel Aviv University, Israel
  • Helmholtz-Zentrum Fuer Infektionsforschung Gmbh, Deutschland
  • Biomedical Sciences Research Center Alexander Fleming, Hellas
  • Ustav Molekularni Genetiky Akademie Ved Ceske Republiky Verejna Vyzkumna Instituce, Ceska Republika
  • European Molecular Biology Laboratory, Deutschland
  • Fundacao Calouste Gulbenkian, Portugal
  • Kobenhavns Universitet, Danmark
  • Genome Research Limited, United Kingdom
  • Toronto Centre For Phenogenomics Inc., Canada
  • Universitat Autonoma De Barcelona, España
  • Stichting Het Nederlands Kanker Instituut, Nederland
  • Medical Research Council, United Kingdom
  • Centre Europeen De Recherche En Biologie Et Medecine, France
  • Veterinaermedizinische Universitaet Wien, Österreich
  • Tse Systems Gmbh, Deutschland
  • Institut National De La Sante Et De La Recherche Medicale (Inserm), France
  • Centre National De La Recherche Scientifique, France