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Combinatorial synthesis of peptide arrays with a laser printer

Activity Code: HEALTH-2007-1.2-1; HEALTH-2007-1.2-2
Coordinator:Helmholtz Zentrum München- German Research Center for Environmental Health


This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide.

The system will operate by:

  • co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by
  • combining XCT information into the FMT inversion to provide a system with superior imaging performance.

XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding correction methods used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities.

Project Details:

Start Date: 01.03.2008
End Date: 29.02.2012
EU Contribution: 4.51 Euro
Total Costs: 5.84 Mio. Euro
Funding Scheme: Collaborative project
Administrative Contact Person: Dr Jürgen Ertel, ertel@helmholtz-muenchen.de
Scientific Coordinator: Prof. Vasilis Ntziachristos, n.ntziachristos@helmholtz-muenchen.de 
Project Website:http://www.fmt-xct.eu/ 


  • Helmholtz Zentrum München- German Research Center for Environmental Health, Germany
  • Fundacion para la Investigacion Biomedica del Hospital Gregoria Marinon, Spain
  • Universität Zürich, Switzerland
  • Commissariat à l'Energie Atomique (CEA), France
  • University College London, United Kingdom
  • Foundation for Research and Technology Hellas, Greece