Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes
Project Reference: 278373
Coordinator:Deutsches Krebsforschungszentrum (German Cancer Research Centre)
Description:
Objective: The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last year's re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen, Enerback & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (diabesity), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.
Project Details:
Start Date: 2011-10-01
End Date: 2015-09-30
Duration: 48 months
EU Contribution: 5,999,998 EURO
Total Costs: 9,958,633 EURO
Funding Scheme: Small or medium-scale focused research project
Programme Acronym: FP7-HEALTH
Programme type: Seventh Framework Programme
Subprogramme Area: Development of novel treatment strategies based on knowledge of cellular dysfunction
Subject index: Medicine, Health, Medical biotechnology
Partners:
- Technische Universitaet Muenchen, Germany
- Centre National de la Recherche Scientifique, France
- Københavns Universitet, Denmark
- Rsita Politecnica delle Marche, Italy
- Universitat de les Illes Balears, Spain
- Institut National de la Sante et de la Recherche Medicale (INSERM), France
- Imperial College of Science, Technology and Medicine, UK
- Miltenyi Biotec GmbH, Germany
- Universite de Geneve, Switzerland
- Goeteborgs Universitet, Sweden
- Universite de Lausanne, Switzerland
- Stockholms Universitet, Sweden
- Eidgenössische Technische Hochschule Zürich, Switzerland
- Technische Universitaet Graz, Austria
- Turun Yliopisto, Finland
- Universiteit Maastricht, Netherlands
- Fyziologicky Ustav Akademie ved Ceske Republiky Verejna Vyzkumna Instituce (VVI), Czech Republic
- Maastricht Instruments, Netherlands
- Evolva Biotech A/S, Denmark