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Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes

Project Reference: 278373
Coordinator:Deutsches Krebsforschungszentrum (German Cancer Research Centre)


Objective: The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last year's re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen, Enerback & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (diabesity), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.

Project Details:

Start Date: 2011-10-01
End Date: 2015-09-30
Duration: 48 months
EU Contribution: 5,999,998 EURO
Total Costs: 9,958,633 EURO
Funding Scheme: Small or medium-scale focused research project
Programme Acronym: FP7-HEALTH
Programme type: Seventh Framework Programme
Subprogramme Area: Development of novel treatment strategies based on knowledge of cellular dysfunction
Subject index: Medicine, Health, Medical biotechnology


  • Technische Universitaet Muenchen, Germany
  • Centre National de la Recherche Scientifique, France
  • Københavns Universitet, Denmark
  • Rsita Politecnica delle Marche, Italy
  • Universitat de les Illes Balears, Spain
  • Institut National de la Sante et de la Recherche Medicale (INSERM), France
  • Imperial College of Science, Technology and Medicine, UK
  • Miltenyi Biotec GmbH, Germany
  • Universite de Geneve, Switzerland
  • Goeteborgs Universitet, Sweden
  • Universite de Lausanne, Switzerland
  • Stockholms Universitet, Sweden
  • Eidgenössische Technische Hochschule Zürich, Switzerland
  • Technische Universitaet Graz, Austria
  • Turun Yliopisto, Finland
  • Universiteit Maastricht, Netherlands
  • Fyziologicky Ustav Akademie ved Ceske Republiky Verejna Vyzkumna Instituce (VVI), Czech Republic
  • Maastricht Instruments, Netherlands
  • Evolva Biotech A/S, Denmark