EUCOMM: Tools for Functional Annotation of the Mouse Genome
Project Reference: 261492
Coordinator: Helmholtz Zentrum München- German Research Center for Environmental Health
Objective: The EUCOMMTOOLS Collaborative Project responds to the topic HEALTH.2010.2.1.1-1: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease. EUCOMMTOOLS will provide, in a systematic high-throughput way, genetic tools and resources contributing to the determination of every gene s function in any cell type of the entire organism at any given point in time. To contribute to the IKMC goals, EUCOMMTOOLS will establish 250 BAC-CreERT2 transgenic mice allowing inducible conditional gene inactivation in most cell types of the organism at any given point in time.
Furthermore, EUCOMMTOOLS will establish 3.500 additional, conditionally targeted mouse ES cells to complete the IKMC resource. In addition, various important technological developments will valorise the EUCOMMTOOLS resources: a genetic toolkit for multipurpose usage of the conditional knockout alleles, and improvements of the Cre-recombinase function. The EUCOMMTOOLS Cre transgenic resource as well as its library of conditionally mutated mouse ES cells enables the establishment of mutant mice world-wide in a standardized, cost-effective and time-saving manner, making mouse mutants more easily available to the wider biomedical research community than possible previously. All EUCOMMTOOLS vectors, mutant ES cells and mice will be displayed via the EUCOMMTOOLS web portal and will be distributed by EuMMCR and EMMA to the scientific community.
In general, EUCOMMTOOLS fosters existing European consortia which address mouse functional genomics, mouse mutant phenotyping, and mouse archiving. Taken together, EUCOMMTOOLS will further advance the functional annotation of the entire mouse genome and thereby enhance the understanding of the molecular basis of disease. Furthermore, it will support drug development by SMEs and the pharmaceutical industry.
Start Date: 2010-10-01
End Date: 2015-09-30
Duration: 60 months
EU Contribution: 11,999,673 EURO
Total Costs: 18,044,564 EURO
Funding Scheme: Large-scale integrating project
Administrative Contact Person: Jürgen ERTEL (Dr)
Programme Acronym: FP7-HEALTH
Programme type: Seventh Framework Programme
Subprogramme Area: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease. FP7-HEALTH-2010-single-stage
Subject index: Medicine, Health, Medical biotechnology
- Centre Europeen de Recherche en Biologie et Medecine, France
- Technische Universität Dresden, Germany
- European Molecular Biology Laboratory, Germany
- Medical Research Council, UK
- Universidad Miguel Hernandez de Elche, Spain
- Consiglio Nazionale delle Ricerche, Italy
- Genome Research Limited, UK