Helmholtz Alliance on Systems Biology
Understanding organisms as a whole
The Helmholtz Alliance on Systems Biology networks in detail
The Helmholtz Alliance on Systems Biology is a consortium of Helmholtz centres in the area of Systems Biology. It consists at the moment out of six interconnected networks working on different biological topics using a systems-oriented perspective. Each network is lead by a specific centre and contains a multitude of different cooperations with other Helmholtz centres and academical as well as non-academical partners. The aim of Helmholtz Alliance on Systems Biology is to deliver a major contribution in the field of systems biology by joining forces and regularly exchanging methods, information and results.
Participating Networks and Centres
Systems Biology of Signalling in Cancer (SBCancer)
German Cancer Research Institute (DKFZ), Heidelberg
The network on Systems Biology of Signalling in Cancer (SBCancer) concentrates on signalling pathways that play a pivotal role in the cellular decisions between proliferation, differentiation and death. Alterations in these signalling pathways and connected gene regulatory networks can change cellular decisions and thereby trigger the onset of tumour formation.
The MDC Systems Biology Network – MSBN
Max-Delbrück Centre for Molecular Medicine (MDC), Berlin-Buch
MSBN focuses on the regulation of disease phenotypes of progressive cardiovascular and neurodegenerative illnesses. Both are characterized by long asymptomatic phases before they become manifest. The regulatory mechanisms that effect first compensation and later pathology shall be investigated and compared, employing a well designed, comprehensive systems biology strategy.
From contaminant molecules to cellular response: system quantification and predictive model development
Helmholtz Centre for Environmental Research (UFZ), Leipzig
The systems biology network of the Centre for environmental research aims at understanding cellular responses to chemical stressors with a systems perspective. This involves analysis of intra-cellular transport of the chemicals, reaction with sub-cellular target sites and the cell's response at the transcriptional and post-transcriptional level. Research is initiated focussing on the cellular response to polycyclic aromatic hydrocarbons, which are known to exert a wide range of toxic effects.
CoReNe: Control of Regulatory Networks with focus on non-coding RNA
Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg
The interdisciplinary network entitled CoReNe focuses on the integrative interpretation of regulatory networks involved in cell differentiation with focus on the interaction of non-coding RNAs (ncRNAs). Focus is put on the influence of ncRNAs on gene expression and thereby on the regulatory networks of the cell. The aim is to extend existing models of regulatory networks by integrating the influence of ncRNAs.
The Human Brain Model: Connecting neuronal structure and function across temporal and spatial scales
Research Centre Jülich (FZJ)
The network entitled "The Human Brain Model" investigates structure function relationships in the human brain as a multi-scale complex system. In particular, the structural, spatial and temporal interactions of different units of the nervous system are analysed on different scales.
Systems Biology at the HZI
Helmholtz Centre for Infection Research (HZI), Braunschweig
Various projects at the HZI work on scientific problems using methodologies from systems biology. These projects include medical as well as biotechnological topics.
- Prof. Dr. Roland Eils
- Coordinator Helmholtz Alliance on Systems Biology
German Cancer Research Center (DKFZ)
- Dr. Jan Eufinger
- Scientifc Project Manager Helmholtz Alliance on Systems Biology
German Cancer Research Center (DKFZ)