The Helmholtz Center for Information Security (CISPA) was integrated into the Helmholtz Association on January 1, 2019 and covers all aspects of information security. It originated from the Center for IT-Security, Privacy, and Accountability (CISPA), which was founded in 2011 with funding by the German Federal Ministry for Education and Research. The Center aims to address the pressing grand cybersecurity research challenges that our society faces in the age of digitalization in a holistic and comprehensive manner and covers the full spectrum from theory to empirical research. It is deep-rooted in the field of Computer Science and works interdisciplinarily with researchers in adjacent fields such as medicine, law, and the social sciences. Its research currently comprises five research areas: Secure and Privacy-friendly Information Processing, Reliable Security Guarantees, Threat Detection and Defenses, Secure Mobile and Autonomous Systems, Empirical and Behavioral Security.