12.11.2012 German Cancer Research Centre

Searching for Defects in Cancer Cell Genomes:

An interdisciplinary German research network with major participation of researchers from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) has sequenced the complete genome of Burkitt lymphoma cancer cells. In their project as part of the International Cancer Genome Consortium (ICGC), the scientists found the genome of Burkitt lymphoma tumor cells mutated in more than 2,000 spots compared to normal cells. The researchers discovered a gene mutated in more than three thirds of all Burkitt lymphomas. This provides new targets for diagnosis and therapy of this aggressive type of lymphoma. The giant amount of data generated in this project is stored and evaluated at DKFZ, where Prof. Roland Eils has been building up a bioinformatics infrastructure for cancer genome sequencing unique in Germany. The results have now been published in the journal Nature Genetics.

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