11.12.2012 Helmholtz Centre for Infection Research

New insights on phagosome maturation

Phagocytes ingest particles as well as pathogens from their surroundings into compartments called phagosomes. The phagosomes possess a harsh milieu with microbicidal function; therefore the phagocytes represent the first line of defense against infections. However, some intracellular pathogens, including members of mycobacterial species, manipulate the phagosomes to survive within them.

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