30.11.2012 German Center for Neurodegenerative Diseases (DZNE)

Molecular knock-out alleviates Alzheimer’s symptoms in mice

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center Göttingen (UMG) have identified an enzyme as a possible target for the treatment of Alzheimer’s disease. The protein known as HDAC6 impairs transport processes within the nerve cells. The scientists observed only mild symptoms of the disease in mice if the enzyme was not produced. They propose to block its activity in a targeted fashion to treat the disease. Scientists from the DZNE sites in Göttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer’s disease. The study is published in "EMBO Molecular Medicine".

Link

more Information