Helmholtz Association

22.10.2008 Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

In the future, the bone marrow transfer to patients with leukaemia could be more secure. Experiments with mice have shown already that certain cells of the immune system (regulatory T cells or Tregs) can suppress the dangerous side effects resulting from the treatment. Such cells control aggressive immune cells and, thus, unwanted immune reactions by the graft can be avoided. However, to date, there were no adequate techniques available to securely isolate the regulatory T cells. Now, Dr. Markus Kleinewietfeld, Dr. Kirsten Falk, and Dr. Olaf Rötzschke of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany and their colleagues of the ‘Fondazione Santa Lucia’ in Rome, Italy have developed a simple method to specifically isolate these cells from human blood.

Donor Cells for Immune Therapy

In the future, the bone marrow transfer to patients with leukaemia could be more secure. Experiments with mice have shown already that certain cells of the immune system (regulatory T cells or Tregs) can suppress the dangerous side effects resulting from the treatment. Such cells control aggressive immune cells and, thus, unwanted immune reactions by the graft can be avoided. However, to date, there were no adequate techniques available to securely isolate the regulatory T cells. Now, Dr. Markus Kleinewietfeld, Dr. Kirsten Falk, and Dr. Olaf Rötzschke of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany and their colleagues of the ‘Fondazione Santa Lucia’ in Rome, Italy have developed a simple method to specifically isolate these cells from human blood.

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13.01.2013

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