Lymphoma Switch

Scientists at the German Cancer Research Center have discovered a molecular switch involved in lymphoma development. When the PP4R1 protein is missing, immune cells can divide uncontrolled, migrate through the body and cause tumours in the skin. The cause for this can be a defect in a specific signal pathway: if certain "off switches" are missing, the signal pathway remains permanently active, resulting in tumours. PP4R1 is one of these central switches and seems to play a role also in other forms of cancer. The researchers now investigate the reason behind the failure to create PP4R1 and hope to derive from it new potential treatment methods.

Further Information:

To the press release of the DKFZ (in German)

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